Index

A

add_bait_column() (in module app.components.interactomics) add_column() (in module app.components.db_functions) add_crapome() (in module app.components.interactomics) add_multiple_records() (in module app.components.db_functions) add_record() (in module app.components.db_functions) additional_controls (app.pipeline_module.pipeline_batch.BatchConfig attribute) analyze() (in module utils.MSParser.MSparser) anova() (in module app.components.quick_stats) app module app (in module app.app) app.app module app.components module app.components.api_tools module app.components.api_tools.apitools module app.components.api_tools.biogrid module app.components.api_tools.intact module app.components.api_tools.uniprot module app.components.cleanup_tasks module app.components.db_functions module app.components.enrichment module app.components.enrichment.pantherdb module app.components.EnrichmentAdmin module app.components.figure_functions module app.components.figures module app.components.figures.bar_graph module app.components.figures.before_after_plot module app.components.figures.color_tools module app.components.figures.commonality_graph module app.components.figures.comparative_plot module app.components.figures.cvplot module app.components.figures.figure_legends module app.components.figures.heatmaps module app.components.figures.histogram module app.components.figures.imputation_histogram module app.components.figures.network_plot module app.components.figures.reproducibility_graph module app.components.figures.scatter module

app.components.figures.tic_graph module app.components.figures.volcano_plot module app.components.file_upload_api module app.components.interactomics module app.components.mathparser module app.components.matrix_functions module app.components.ms_microscopy module app.components.MS_run_json_parser module app.components.parsing module app.components.proteomics module app.components.qc_analysis module app.components.quick_stats module app.components.text_handling module app.components.tools module app.components.tools.R_tools module app.components.tools.utils module app.components.tooltips module app.components.ui_components module app.database_admin module app.database_updater module app.element_styles module app.embedded_page_updater module app.pages module app.pipeline_module module app.pipeline_module.batch_data_store_builder module app.pipeline_module.batch_figure_builder_from_divs module app.pipeline_module.pipeline_batch module app.pipeline_module.pipeline_from_toml module app.pipeline_module.pipeline_input_watcher module app.resources module app.resources.get_cpu_count module app.run_as_pipeline module

B

bar_plot() (in module app.components.figures.bar_graph) BatchConfig (class in app.pipeline_module.pipeline_batch) bits (app.components.figures.commonality_graph.Intersection attribute) build_analysis_divs_from_saved_divs() (in module app.pipeline_module.batch_figure_builder_from_divs) build_data_stores_from_batch_output() (in module app.pipeline_module.batch_data_store_builder)

build_interactomics_data_stores() (in module app.pipeline_module.batch_data_store_builder) build_proteomics_data_stores() (in module app.pipeline_module.batch_data_store_builder) build_qc_data_stores() (in module app.pipeline_module.batch_data_store_builder) build_replicate_colors_stores() (in module app.pipeline_module.batch_data_store_builder) build_upload_data_store() (in module app.pipeline_module.batch_data_store_builder)

C

calculate_auc() (in module utils.MSParser.MSparser) celery_app (in module app.app) check_bait() (in module app.components.parsing) check_comparison_file() (in module app.components.parsing) check_numeric() (in module app.components.parsing) check_required_columns() (in module app.components.parsing) check_sample_table_column() (in module app.components.parsing) checklist() (in module app.components.ui_components) chosen_enrichments (app.pipeline_module.pipeline_batch.BatchConfig attribute) clean_column_name() (in module app.components.parsing) clean_database() (in module app.database_admin) clean_sample_names() (in module app.components.parsing) clean_text() (in module app.components.text_handling) clustermap() (in module app.components.proteomics) common_proteins() (in module app.components.qc_analysis) commonality_plot() (in module app.components.qc_analysis) comparison_file (app.pipeline_module.pipeline_batch.BatchConfig attribute)

compute_zscore() (in module app.components.matrix_functions) compute_zscore_based_deviation_from_control() (in module app.components.matrix_functions) control_group (app.pipeline_module.pipeline_batch.BatchConfig attribute) count_intercepts() (in module utils.MSParser.MSparser) count_knowns() (in module app.components.interactomics) count_per_sample() (in module app.components.matrix_functions) count_plot() (in module app.components.qc_analysis) coverage_plot() (in module app.components.qc_analysis) crapome_fc_threshold (app.pipeline_module.pipeline_batch.BatchConfig attribute) crapome_percentage_threshold (app.pipeline_module.pipeline_batch.BatchConfig attribute) crapome_sets (app.pipeline_module.pipeline_batch.BatchConfig attribute) create_connection() (in module app.components.db_functions) create_data_store_component() (in module app.pipeline_module.batch_data_store_builder) create_dummy_list_txt() (in module app.components.interactomics) create_navbar() (in module app.app) create_page_file() (in module app.embedded_page_updater) create_sqlite_from_schema() (in module app.database_admin) create_upset_figure() (in module app.components.figures.commonality_graph)

D

darken() (in module app.components.figures.color_tools) dash_to_wire() (in module app.pipeline_module.pipeline_batch) data_store_export_configuration (in module app.components.infra) DATA_STORE_IDS (in module app.components.infra) data_table_path (app.pipeline_module.pipeline_batch.BatchConfig attribute) deduplicate_nested_dicts() (in module utils.MSParser.parse_thermo) deduplicate_str_dataframe_by_index() (in module app.components.api_tools.biogrid) deep_merge() (in module app.components.tools.utils) delete_multiple_records() (in module app.components.db_functions) delete_record() (in module app.components.db_functions) delete_samples() (in module app.components.parsing) differential() (in module app.components.quick_stats) differential_abundance() (in module app.components.proteomics) dig_dict() (in module app.components.tools.utils) discard_samples_checklist() (in module app.components.ui_components)

distribution_plot() (in module app.components.qc_analysis) do_ms_microscopy() (in module app.components.interactomics) do_network() (in module app.components.interactomics) do_pca() (in module app.components.matrix_functions) do_update() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) download_full_uniprot_for_organism() (in module app.components.api_tools.uniprot) download_intact_ftp() (in module app.components.api_tools.intact) download_uniprot_chunks() (in module app.components.api_tools.uniprot) download_uniprot_for_database() (in module app.components.api_tools.uniprot) download_uniprot_pagination_url() (in module app.components.api_tools.uniprot) draw_clustergram() (in module app.components.figures.heatmaps) draw_localization_heatmap() (in module app.components.ms_microscopy) draw_localization_plot() (in module app.components.ms_microscopy) drop_table() (in module app.components.db_functions) dump_full_database_to_csv() (in module app.components.db_functions)

E

enrich() (app.components.enrichment.pantherdb.handler method) (in module app.components.interactomics) enrich_all() (app.components.EnrichmentAdmin.EnrichmentAdmin method) enrichment_legend() (in module app.components.figures.figure_legends)

EnrichmentAdmin (class in app.components.EnrichmentAdmin) eval_() (app.components.mathparser.MathParser method) expand_path() (in module app.components.tools.utils) expand_paths() (in module app.components.tools.utils) export_snapshot() (in module app.components.db_functions)

F

fc_threshold (app.pipeline_module.pipeline_batch.BatchConfig attribute) figure_export_directories (in module app.components.infra) figure_template (app.pipeline_module.pipeline_batch.BatchConfig attribute) filter_chunk() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact)

filter_controls_by_similarity() (in module app.components.interactomics) filter_missing() (in module app.components.matrix_functions) force_supervenn (app.pipeline_module.pipeline_batch.BatchConfig attribute) format_data() (in module app.components.parsing) format_sample_group_name() (in module app.components.parsing)

G

generate_commonality_container() (in module app.components.qc_analysis) generate_database_table_templates_as_tsvs() (in module app.components.db_functions) generate_graphs() (in module app.components.figures.volcano_plot) generate_msmic_dataframes() (in module app.components.ms_microscopy) generate_pandas() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) generate_replicate_name() (in module app.components.parsing) generate_saint_container() (in module app.components.interactomics) generic_tooltip() (in module app.components.tooltips) get_all_props() (in module app.components.infra) get_all_types() (in module app.components.infra) get_assigned_colors() (in module app.components.figures.color_tools) get_available() (app.components.enrichment.pantherdb.handler method) (app.components.EnrichmentAdmin.EnrichmentAdmin method) (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) get_common_data() (in module app.components.quick_stats) get_commonality_pdf_data() (in module app.pipeline_module.batch_figure_builder_from_divs) get_comparative_data() (in module app.components.quick_stats) get_contaminants() (in module app.components.db_functions) get_count_data() (in module app.components.quick_stats) get_coverage_data() (in module app.components.quick_stats) get_cut_colors() (in module app.components.figures.color_tools) get_cytoscape_container() (in module app.components.figures.network_plot) get_cytoscape_elements_and_ints() (in module app.components.figures.network_plot) get_database_versions() (in module app.components.db_functions) get_dataframe_differences() (in module app.database_updater) get_default() (app.components.EnrichmentAdmin.EnrichmentAdmin method) get_default_panel() (app.components.enrichment.pantherdb.handler method) get_default_uniprot_column_map() (in module app.components.api_tools.uniprot) get_directory_size() (in module utils.MSParser.parse_timstof) get_disabled() (app.components.EnrichmentAdmin.EnrichmentAdmin method) get_distribution_title() (in module app.components.parsing) get_external_versions() (in module app.database_admin)

get_files_newer_than() (in module app.components.api_tools.apitools) get_final_df() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) get_from_table() (in module app.components.db_functions) get_from_table_by_list_criteria() (in module app.components.db_functions) get_from_table_match_with_priority() (in module app.components.db_functions) get_full_table_as_pd() (in module app.components.db_functions) get_ids() (in module app.components.api_tools.intact) get_iso() (in module app.components.api_tools.intact) get_last_update() (in module app.components.db_functions) get_latest() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) get_max() (in module app.components.figures.reproducibility_graph) get_mean_data() (in module app.components.quick_stats) get_method_annotation() (in module app.components.api_tools.biogrid) get_na_data() (in module app.components.quick_stats) get_nbibfile() (in module app.components.api_tools.apitools) get_newest_file() (in module app.components.api_tools.apitools) get_org() (in module app.components.api_tools.intact) get_pantherdb_datasets() (app.components.enrichment.pantherdb.handler method) get_pub_ref() (in module app.components.api_tools.apitools) get_reproducibility_dataframe() (in module app.components.figures.reproducibility_graph) get_saint_matrix() (in module app.components.interactomics) get_save_location() (in module app.components.api_tools.apitools) get_scantypes() (in module utils.MSParser.parse_thermo) get_stylesheet() (in module app.components.figures.network_plot) get_sum_data() (in module app.components.quick_stats) get_table_column_names() (in module app.components.db_functions) get_timestamp() (in module app.components.api_tools.apitools) get_traces() (in module utils.MSParser.parse_thermo) (in module utils.MSParser.parse_timstof) get_uniprot_column_map() (in module app.components.api_tools.uniprot) get_upid() (in module app.components.api_tools.biogrid) guess_controls() (in module app.components.parsing)

H

handle_and_split_save() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) handle_data() (in module utils.MSParser.MSparser) handle_merg_chunk() (in module app.database_updater) handle_mods() (in module app.database_updater)

handle_mztab() (in module app.components.parsing) handle_new() (in module app.database_updater) handler (class in app.components.enrichment.pantherdb) HEADER_DICT (in module app.components.ui_components) hierarchical_clustering() (in module app.components.matrix_functions)

I

identify() (in module utils.MSParser.ms_name_identifier) identify_columns() (in module app.components.parsing) import_handlers() (app.components.EnrichmentAdmin.EnrichmentAdmin method) improve_text_position() (in module app.components.figure_functions) imputation (app.pipeline_module.pipeline_batch.BatchConfig attribute) imputation() (in module app.components.proteomics) impute() (in module app.components.matrix_functions) impute_gaussian() (in module app.components.matrix_functions) impute_minprob() (in module app.components.matrix_functions) impute_minprob_df() (in module app.components.matrix_functions) impute_minval() (in module app.components.matrix_functions) impute_qrilc() (in module app.components.tools.R_tools)

impute_random_forest() (in module app.components.tools.R_tools) interactomics_area() (in module app.components.ui_components) interactomics_control_col() (in module app.components.ui_components) interactomics_crapome_col() (in module app.components.ui_components) interactomics_enrichment_col() (in module app.components.ui_components) interactomics_inbuilt_control_col() (in module app.components.ui_components) interactomics_input_card() (in module app.components.ui_components) interactomics_select_top_controls_tooltip() (in module app.components.tooltips) Intersection (class in app.components.figures.commonality_graph) is_newer() (in module app.components.api_tools.apitools) is_newer_available() (in module app.components.api_tools.uniprot) is_test_db() (in module app.components.db_functions)

K

keep_batch_output (app.pipeline_module.pipeline_batch.BatchConfig attribute)

known_plot() (in module app.components.interactomics)

L

label (app.components.figures.commonality_graph.Intersection attribute) last_update() (in module app.database_admin) leg_rep() (in module app.components.figures.figure_legends) list_tables() (in module app.components.db_functions) load_config() (in module app.pipeline_module.pipeline_from_toml)

load_div_pickle() (in module app.pipeline_module.batch_figure_builder_from_divs) load_pipeline_parameters() (in module app.pipeline_module.pipeline_from_toml) load_toml() (in module app.components.tools.utils) localization_graph() (in module app.components.ms_microscopy) logger (in module app.app) (in module app.components.interactomics)

M

main() (in module app.app) (in module app.database_admin) (in module app.pipeline_module.batch_figure_builder_from_divs) (in module app.run_as_pipeline) (in module utils.MSParser.MSparser) main_content_div() (in module app.components.ui_components) main_sidebar() (in module app.components.ui_components) make_du_uploader() (in module app.components.ui_components) make_figure() (in module app.components.figures.histogram) (in module app.components.figures.scatter) make_graph() (in module app.components.figures.bar_graph) (in module app.components.figures.before_after_plot) (in module app.components.figures.commonality_graph) (in module app.components.figures.comparative_plot) (in module app.components.figures.cvplot) (in module app.components.figures.imputation_histogram) (in module app.components.figures.reproducibility_graph) (in module app.components.figures.scatter) make_heatmap_graph() (in module app.components.figures.heatmaps) make_saint_dict() (in module app.components.interactomics) map_intensity() (in module app.components.interactomics) map_protein_info() (in module app.components.db_functions) MathParser (class in app.components.mathparser) mean_plot() (in module app.components.qc_analysis) median_normalize() (in module app.components.matrix_functions) merge_multiple_string_dataframes() (in module app.database_updater) methods_text() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) (in module app.components.api_tools.uniprot) missing_plot() (in module app.components.qc_analysis) missing_values_in_other_samples() (in module app.components.proteomics) modals() (in module app.components.ui_components) modify_multiple_records() (in module app.components.db_functions) modify_record() (in module app.components.db_functions) module app app.app app.components app.components.api_tools app.components.api_tools.apitools app.components.api_tools.biogrid app.components.api_tools.intact app.components.api_tools.uniprot app.components.cleanup_tasks app.components.db_functions app.components.enrichment app.components.enrichment.pantherdb app.components.EnrichmentAdmin app.components.figure_functions app.components.figures app.components.figures.bar_graph app.components.figures.before_after_plot app.components.figures.color_tools app.components.figures.commonality_graph app.components.figures.comparative_plot app.components.figures.cvplot app.components.figures.figure_legends app.components.figures.heatmaps app.components.figures.histogram app.components.figures.imputation_histogram app.components.figures.network_plot app.components.figures.reproducibility_graph app.components.figures.scatter app.components.figures.tic_graph app.components.figures.volcano_plot app.components.file_upload_api app.components.interactomics app.components.mathparser app.components.matrix_functions app.components.ms_microscopy app.components.MS_run_json_parser app.components.parsing app.components.proteomics app.components.qc_analysis app.components.quick_stats app.components.text_handling app.components.tools app.components.tools.R_tools app.components.tools.utils app.components.tooltips app.components.ui_components app.database_admin app.database_updater app.element_styles app.embedded_page_updater app.pages app.pipeline_module app.pipeline_module.batch_data_store_builder app.pipeline_module.batch_figure_builder_from_divs app.pipeline_module.pipeline_batch app.pipeline_module.pipeline_from_toml app.pipeline_module.pipeline_input_watcher app.resources app.resources.get_cpu_count app.run_as_pipeline utils.MSParser utils.MSParser.ms_name_identifier utils.MSParser.MSparser utils.MSParser.parse_thermo utils.MSParser.parse_timstof

N

n_controls (app.pipeline_module.pipeline_batch.BatchConfig attribute) na_filter() (in module app.components.proteomics) na_filter_percent (app.pipeline_module.pipeline_batch.BatchConfig attribute) na_filter_type (app.pipeline_module.pipeline_batch.BatchConfig attribute) na_tooltip() (in module app.components.tooltips) navbar() (in module app.components.ui_components)

nearest_tooltip() (in module app.components.tooltips) network_display_data() (in module app.components.interactomics) nice_name (app.components.enrichment.pantherdb.handler property) normalization (app.pipeline_module.pipeline_batch.BatchConfig attribute) normalization() (in module app.components.proteomics) normalize() (in module app.components.matrix_functions) normalize_key() (in module app.components.tools.utils)

O

only_latest_date() (in module app.components.api_tools.intact)

outdir (app.pipeline_module.pipeline_batch.BatchConfig attribute)

P

p_threshold (app.pipeline_module.pipeline_batch.BatchConfig attribute) panel_to_usable() (app.components.enrichment.pantherdb.handler method) parse() (app.components.mathparser.MathParser method) parse_comparisons() (in module app.components.parsing) parse_d() (in module utils.MSParser.MSparser) parse_data_file() (in module app.components.parsing) parse_embed_file() (in module app.embedded_page_updater) parse_file() (in module utils.MSParser.parse_thermo) (in module utils.MSParser.parse_timstof) parse_parameters() (in module app.components.parsing) parse_raw() (in module utils.MSParser.MSparser) parse_sample_table() (in module app.components.parsing)

parse_tic_data() (in module app.components.qc_analysis) parse_timestamp_from_str() (in module app.components.api_tools.apitools) pca() (in module app.components.interactomics) (in module app.components.proteomics) perc_cvplot() (in module app.components.proteomics) plot_formats (app.pipeline_module.pipeline_batch.BatchConfig attribute) post_saint_container() (in module app.components.ui_components) prefix_relative_paths() (in module app.components.tools.utils) prepare_controls() (in module app.components.interactomics) prepare_crapome() (in module app.components.interactomics) proteomics_area() (in module app.components.ui_components) proteomics_input_card() (in module app.components.ui_components) proximity_filtering (app.pipeline_module.pipeline_batch.BatchConfig attribute)

Q

qc_area() (in module app.components.ui_components)

quantile_normalize() (in module app.components.matrix_functions)

R

range_input() (in module app.components.ui_components) ranked_dist() (in module app.components.matrix_functions) ranked_dist_n_per_run() (in module app.components.matrix_functions) read_data_from_content() (in module app.components.parsing) read_df_from_content() (in module app.components.parsing) read_dia_nn() (in module app.components.parsing) read_file_chunks() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) read_folder_chunks() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) read_fragpipe() (in module app.components.parsing) read_matrix() (in module app.components.parsing) read_toml() (in module app.components.tools.utils) (in module utils.MSParser.MSparser) register_file_upload_api() (in module app.components.file_upload_api) remove_accent_characters() (in module app.components.text_handling) (in module utils.MSParser.MSparser) remove_all_na() (in module app.components.parsing) remove_column() (in module app.components.db_functions) remove_common_contaminants (app.pipeline_module.pipeline_batch.BatchConfig attribute) remove_duplicate_protein_groups() (in module app.components.parsing) remove_file_path() (in module app.components.parsing) remove_filepath_from_columns() (in module app.components.parsing)

remove_from_table() (in module app.components.parsing) remove_rawfile_ending() (in module app.components.parsing) (in module utils.MSParser.MSparser) remove_unwanted_colors() (in module app.components.figures.color_tools) rename_column() (in module app.components.db_functions) rename_columns_and_update_expdesign() (in module app.components.parsing) rename_replicates (app.pipeline_module.pipeline_batch.BatchConfig attribute) replace_accent_and_special_characters() (in module app.components.text_handling) replace_special_characters() (in module app.components.text_handling) (in module utils.MSParser.MSparser) reproducibility_plot() (in module app.components.qc_analysis) rescue_enabled (app.pipeline_module.pipeline_batch.BatchConfig attribute) rescue_tooltip() (in module app.components.tooltips) retrieve_pantherdb_gene_classification() (app.components.enrichment.pantherdb.handler method) retrieve_protein_group() (in module app.components.api_tools.uniprot) retrieve_uniprot() (in module app.components.api_tools.uniprot) reverse_log2() (in module app.components.matrix_functions) rgba_to_hex() (in module app.components.figures.color_tools) roundup() (in module utils.MSParser.parse_thermo) run_batch_pipeline() (in module app.run_as_pipeline) run_panther_overrepresentation_analysis() (app.components.enrichment.pantherdb.handler method) run_pipeline() (in module app.pipeline_module.pipeline_batch) run_rscript() (in module app.components.tools.R_tools) run_saint() (in module app.components.interactomics)

S

saint_bfdr_threshold (app.pipeline_module.pipeline_batch.BatchConfig attribute) saint_cmd() (in module app.components.interactomics) saint_counts() (in module app.components.interactomics) saint_filtering() (in module app.components.interactomics) saint_filtering_container() (in module app.components.ui_components) saint_histogram() (in module app.components.interactomics) saint_legend() (in module app.components.figures.figure_legends) sample_table_path (app.pipeline_module.pipeline_batch.BatchConfig attribute) sanitize_for_database_use() (in module app.components.text_handling) save_batch_data_using_infra() (in module app.pipeline_module.batch_data_store_builder) save_batch_figures_using_saved_divs() (in module app.pipeline_module.batch_figure_builder_from_divs)

save_data_stores() (in module app.components.infra) save_figures() (in module app.components.infra) save_input_information() (in module app.components.infra) save_toml() (in module app.components.tools.utils) sdrf_to_table() (in module app.components.parsing) server (in module app.app) size (app.components.figures.commonality_graph.Intersection attribute) split_and_save_by_prefix() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) stream_flattened_rows() (in module app.database_updater) sum_plot() (in module app.components.qc_analysis)

T

table_of_contents() (in module app.components.ui_components) test_type (app.pipeline_module.pipeline_batch.BatchConfig attribute) test_type_tooltip() (in module app.components.tooltips)

tic_figure() (in module app.components.figures.tic_graph) toggle_navbar_collapse() (in module app.app) tweak_fig_size_hw() (in module app.components.ms_microscopy)

U

unique_only (app.pipeline_module.pipeline_batch.BatchConfig attribute) unmix_dtypes() (in module app.components.parsing) update() (in module app.components.api_tools.biogrid) (in module app.components.api_tools.intact) (in module app.components.api_tools.uniprot) update_database() (in module app.database_updater) update_external_data() (in module app.database_updater) update_knowns() (in module app.database_updater) update_log_table() (in module app.database_updater) update_nested_dict() (in module app.components.parsing) update_pages() (in module app.embedded_page_updater) update_table_with_file() (in module app.database_updater) update_uniprot() (in module app.database_updater)

update_version_table() (in module app.database_updater) upload_area() (in module app.components.ui_components) upload_data_stores() (in module app.components.infra) uploaded_controls (app.pipeline_module.pipeline_batch.BatchConfig attribute) utils.MSParser module utils.MSParser.ms_name_identifier module utils.MSParser.MSparser module utils.MSParser.parse_thermo module utils.MSParser.parse_timstof module

V

validate_basic_inputs() (in module app.components.parsing) volcano_heatmap_legend() (in module app.components.figures.figure_legends)

volcano_plot() (in module app.components.figures.volcano_plot) volcano_plot_legend() (in module app.components.figures.figure_legends) vsn() (in module app.components.tools.R_tools)

W

workflow (app.pipeline_module.pipeline_batch.BatchConfig attribute)

workflow_area() (in module app.components.ui_components) working_data_stores() (in module app.components.infra)

Z

zipdir() (in module app.components.tools.utils)